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1 Collectively, tumor-intrinsic mechanisms, spanning genetic mutation, epigenetic reprogramming, immune checkpoint activation, and cellular plasticity, converge to create a highly adaptable, treatment-refractory phenotype

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Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) is commonly used for the bioanalysis of GLP-1 analogues and biomarkers, but the method development faces three challenges: High interference and low sensitivity Due to the low intestinal absorption and poor proteolytic stability in the gastrointestinal tract, drug concentrations of GLP-1 analogues following oral administration are generally low

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610 At present, the pathogenesis and treatment of ferroptosis are hot topics in the field of PD research, indicating that the targeted treatment of ferroptosis is a potential method to prevent and treat PD

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